Managing patients on warfarin therapy in a cost-effective way can be a challenge for physicians because of a narrow therapeutic dosing range, inefficient office workflow models and other factors.

But there is a solution - one that can benefit both physicians and their patients.

Systematic anticoagulation management (SAM) is a patient-focues approach that utilizes PT/INR testing at the point of care rather than through an outside lab.  Multiple studies have shown that this approach may increase the time patients are in range and reduce adverse events. 1,2,3,4

Improved patient care. By improving consistency in results, SAM has been shown to increase patients' average time in therapeutic range by as much as 97%2 and significantly reduce thromboembolic and hemorrhagic events - as well as the costs associated with them. 2,5,6,7




 1  Jacobson A, Guilloteau F, Campbell P, Denham C. Comparison of point of care testing and standard reference laboratory testing for PT/INR measurements in patients receiving routine warfarin therapy: an engineering work process flow study. Dis Manage Clin Outcomes. 2000;2.
 2  Wurster M, Doran T. Anticoagulation management: A new approach. Disease Management. 2006;4:201-209. 
 3  Jacobson AK. In: Ansell JE et al., eds. Managing Oral Anticoagulation Therapy. 2nd ed. St. Louis, Mo.: Facts and Comparisons; 2003:45:1-6. 
 4  Campbell P, Radensky P, Denham C. Economic analysis of systematic anticoagulation management vs. routine care for patients on oral warfarin therapy. Dis Manage Clin Outcomes. 2000;2:1-8. 
 5  Heneghan C, Alonso-Coello P, Garcia-Alamino JM, et al. Self-monitoring of oral anticoagulation: a systematic review and meta-analysis. Lancet. 2006;367:404-411. 
 6  Finck KM, Doetkott C, Miller DR. Clinical impact of interlaboratory variation in international normalized ratio determinations. Am J Health Syst Pharm. 2001;58:684-688.
 7  Gardiner C, Williams K, Mackle JJ, Machin SJ, Cohen H. Patient self-testing is a reliable and acceptable alternative to laboratory INR monitoring. British Journal of Haematology. 2004;128:242-247.